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KMID : 0602820000060010029
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Korean Journal of Bronchoesophagology
2000 Volume.6 No. 1 p.29 ~ p.37
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Expression of Laminin in Rat Tracheal Mucosa after Exposure to Sulfur Dioxide Gas
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이형석/Hyung Seok Lee
유연희/조석현/김경래/정호삼/Yean Hee Yu/Seok Hyun Cho/Kyung Rae Kim/Ho Sam Chung
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Abstract
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Background and Objectives:The concentration of sulfur dioxide(SO2) gas in the ambient air appears increasing in the industry and urban area day by day. It was known that SO2 is noxious gas. SO2 can be
irritating
to the eyes, nose, throat, upper respiratory tract and skin. It produces sulfurous acid on contact with water and is extremely irritating to the nasopharynx and respiratory tract. Laminin is a family of extracellular matrix glycoproteins
localized
in
the basement membrane that separates epithelial cells from the underlying stroma. The biological activities of laminin are to promote cell migration, wound healing, growth and differentiation.Meterials and Methods:The histologic changes
and
the
expression of laminin in tracheal mucosa sacrificed at every weeks (to 7 weeks) after continued SO2 exposure of 250ppm for 30 minutes a day were studied in rats.Results:Pathologic tissue was formed at the tracheal mucosa and the
underlying tissue by the infiltration of monocytes and epithelium was transformed to the single cell layered epithelium above 5 weeks after exposure. At the 6 weeks after exposure, epithelial cells were partially lost and epithelial cell layer
was
transformed to be leaf-shaped. Submucosal tissue was transformed to be lymphatic tissue. An intense positive staining for laminin was found in apical cytoplasm and lateral surface of the normal epithelial cells and basement membrane but at the 5
and 6
weeks after exposure, laminin activity was decreased to the moderate activity. At the 7 weeks after exposure, laminin activity was decreased to the weak activity.Conclusion:Our finding suggests that SO2 makes histologic damage
on
the
tracheal mucosa and decreases immunoreactivity for laminin. Longer duration of the exposure of SO2 makes more histologic damage on the tracheal mucosa and decreases immunoreactivity for laminin.
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KEYWORD
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